تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Estimation of Interleukin‐1β Promoter (− 31 C/T and− 511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients Estimation of Interleukin‐1β Promoter (− 31 C/T and− 511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients |
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لغة الوثيقة |
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العربية |
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المستخلص |
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Interleukin-1b (IL-1b) is an inflammation-causing cytokine that exerts several unique biological effects and could lead to future adverse
events of CAD. The piece of work presented herein is aimed at investigating possible association of IL-1b levels to its polymorphic site
viz. 511 and 31 at promoter region in Saudi CAD patients. The study included 155 confirmed CAD patients and 80 healthy control
individuals both men and women. Concentration of IL-1b in the patients’ serum was measured by ELISA method. For single nucleotide
polymorphism (SNP) analysis, sanger method of DNA sequencing was followed. We observed variable numbers of SNPs at 31 C/T and 511
T/C promoter regions in Saudi patients suffering from CAD in comparison to the control set of individuals. However, the changes in the number
of SNP-hotspots were determined to be non-significant with reference to the control set. The haplotype analysis at 31 and 511 also did not
show any significant changes between control and CAD patients. Moreover, serum IL-1b levels were observed to be expressively higher in
patients suffering from CAD (P<0.001) and its associated complications viz. STEMI (P<0.001), NSTEMI (P<0.001), and UA (P<0.001). Our
study provides the status of SNPs at IL-1b promoter in Saudi population. As per our information, ours is the first article that shows the genetic
diversity in IL-1b promoters and its level in the Saudi CAD patients. J. Cell. Biochem. 9999: 1–6, 2017. © 2017 Wiley Periodicals, Inc. |
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ردمد |
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1097-4644 |
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اسم الدورية |
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Journal of Cellular Biochemistry |
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المجلد |
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1 |
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العدد |
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1 |
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سنة النشر |
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1438 هـ
2017 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Tuesday, May 16, 2017 |
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الباحثون
| Shams Tabrez | Tabrez, Shams | باحث رئيسي | دكتوراه | |
| Nasimudeen R Jabir | Jabir, Nasimudeen R | باحث | دكتوراه | |
| Chelapram K Firoz | Firoz, Chelapram K | باحث | دكتوراه | |
| Salwa Hindawi | Hindawi, Salwa | باحث | دكتوراه | |
| Shazi Shakil | Shakil, Shazi | باحث | دكتوراه | |
| Ghazi A Damanhouri | Damanhouri, Ghazi A | باحث | دكتوراه | |
| Syed Kashif Zaidi | Zaidi, Syed Kashif | باحث | دكتوراه | |
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الرجوع إلى صفحة الأبحاث
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